Systems Learning of Single Cells
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：Qing Nie (University of California, Irvine)
： 2024-11-06 16:30
：Conference Room C503 at Administration Building at Haiyun Campus
Speaker：Qing Nie (University of California, Irvine)
Time：2024-11-6, 16:30
Location：Conference Room C503 at Administration Building at Haiyun Campus
Abstract:
Cells make fate decisions in response to dynamic environments, and multicellular structures emerge from multiscale interplays among cells and genes in space and time. The recent single-cell genomics technology provides an unprecedented opportunity to profile cells for all their genes. While those measurements provide high-dimensional gene expression profiles for all cells, it requires fixing individual cells that lose many important spatiotemporal information. Is it possible to infer temporal relationships among cells from single or multiple snapshots? How to recover spatial interactions among cells, for example, cell-cell communication? In this talk I will present our newly developed computational tools to study cell fate in the context of single cells as a system. In particular, I will show dynamical models and machine-learning methods, with a focus on inference and analysis of transitional properties of cells and cell-cell communication using both high-dimensional single-cell and spatial transcriptomics, as well as multi-omics data for some cases. Through their applications to various complex systems in development, regeneration, and diseases, we show the discovery power of such methods in addition to identifying areas for further method development for spatiotemporal analysis of single-cell data.
